engleski

HLA haplotypes associated with familial jjuvenile onset psoriasis in Croatian patients

The aim of the study was to identify disease-associated HLA alleles and haplotypes in Croatian patients(pts), and to determine whether the same HLA risk alleles and haplotypes are involved in an early and late disease onset. 138 unrelated pts with type I psoriasis(early onset < 40 years, positive family history) were divided in two groups according to disease onset(1a:<20 years, 78 pts. and 1b:>20 years, 60 pts). 26 pts in the group 1a presented as psoriasis guttata. Volunteer blood donors were HLA type as a control (n=181). High-resolution PCR-based typing for HLA class I and II was performed. 30.77% pts in group 1a and 25.0% pts in group 1b were positive for B*13-Cw*0602 compared to 4.97% in control (p=0.006 and 0.0218 respectively). 25.64% pts in group 1a and 18.33% pts in group1b presented B*57-Cw*0602 compared to 3.31% in control (p=0.0129 and 0.01775 respectively). In psoriasis guttata group 42.31% pts demonstrated B*13-Cw*0602 and 15.38% of them B*57-Cw*0602, compared to control, 4.97% and 3.31% (p=0.00599 and 0.1204, respectively). Early psoriasis onset (<20 years and familial history) is more significantly associated with B*13-Cw*0602 haplotype (p=0.00599 for psoriasis guttata and p=0.00604 for type 1a), than with B*57-Cw*0602 (p=0.1204 for psoriasis guttata and 0.01396 for type 1a).

HLA haplotypes; psoriasis vulgaris; juvenile onset; Croatia

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