Croatian genetic heritage: an updated Y-chromosome story (CROSBI ID 733739)
Prilog sa skupa u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Primorac, Dragan ; Škaro, Vedrana ; Projić, Petar ; Missoni, Saša ; Horjan Zanki, Ivana ; Merkaš, Siniša ; Šarac, Jelena ; Novokmet, Natalija ; Ledić, Andrea ; Makar, Adela ; Lauc, Gordan ; Anđelinović, Šimun ; Bašić, Željana ; Kružić, Ivana ; Neuberg, Marijana ; Smolić, Martina ; Smolić, Robert ; Hrstić, Irena ; Trivanović, Dragan ; Konjhodžić, Rijad ; Salihefendić, Lana ; Jordamović, Naida Babić ; Marjanović, Damir
engleski
Croatian genetic heritage: an updated Y-chromosome story
Aim To analyze an additional set of 'Y-chromosome genetic markers to acquire a more detailed insight into the diversity of the Croatian population. Methods A total of 518 Yfiler Plus profiles were genotyped. Allele frequencies, haplotype frequencies, and haplotype diversity were calculated by using the STRAF software v. 2.0.4. Genetic distances were quantified by Rst with AMOVA online tool from the YHRD. The evolutionary history was inferred with the neighbor-joining method of phylogenetic tree construction in the MEGAX software. Whit Athey's Haplogroup Predictor v. 5 was used for additional comparison with regional and other European populations. Results A total of 507 haplotypes were used for genetic STR analysis. An interpopulation study on 17 Y-STR markers showed the lowest genetic diversity between the Croatian and Bosnian-Herzegovinian populations and the highest between the Croatian and Irish populations. Additional interpopulation comparison with the original 27 Y-STR markers (for the population with available data) was also performed. A total of 518 haplotypes were used in the determination of haplogroup diversity. Haplogroup I with its sublineage I2a expressed the highest prevalence. The second most prevalent haplogroup was R, with its major sublineage R1a, except for the subpopulation of Hvar, where E1b1b was the second most prevalent haplogroup. Rare haplogroups also confirmed in this study were L, T, and Q. G1 was detected for the first time in the Croatian population. Conclusion We obtained a new insight into the differences between examined subpopulations of Croatia and their possible (dis)similarities with neighboring and distant populations.
Chromosomes, Human, Y ; Croatia ; Genetic Variation ; Genetics, Population ; Haplotypes ; Humans ; Microsatellite Repeats ; Phylogeny
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Podaci o prilogu
273-286.
2022.
63 (3)
objavljeno
10.3325/cmj.2022.63.273
Podaci o matičnoj publikaciji
Croatian medical journal
Zagreb: Hrvatski liječnički zbor
0353-9504
1332-8166
Podaci o skupu
12th ISABS Conference
predavanje
22.06.2022-27.06.2022
Dubrovnik, Hrvatska
Povezanost rada
Temeljne medicinske znanosti