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Stable Gastric Pentadecapeptide BPC 157 and NO-System

Stable gastric pentadecapeptide BPC 157 is known with very safe profile when used to be in ulcerative colitis and now multiple sclerosis trial, lethal dose (LD1) not achieved. Its pleiotropic beneficial effects were largely combined with its particular modulatory effect on NO-system functions, providing that BPC 157 may counteract adverse effect of nitric oxide synthase (NOS)-blocker L-NAME and NOS-substrate, L-arginine. Previous review emphasized the large range of relationships between and NO-system. These relationships were described as those on (i) gastric mucosa and mucosal protection, following alcohol lesions, in cytoprotection course, NO-generation, and blood pressure regulation ; (ii) alcohol acute/chronic intoxication, and withdrawal ; (iii) cardiovascular disturbances, chronic heart failure, pulmonary hypertension, and arrhythmias ; (iv) disturbances after hypokalemia and hyperkalemia, and potassium-cell membrane dysfunction and (v) complex healing failure, proved by the fistulas healing. Further studies revealed additional particular relations on sphincter function, free radicals induced injuries, bleeding, non-specific and specific NSAIDs-induced lesions, general anesthesia (thiopental)- and local anesthesia (lidocaine)-induced disturbances, rat models that resemble schizophreniapositive symptoms and most importantly, with organs lesions, or with vessels occlusion, the effect on the vessels presentation, and recruitment of additional collateral pathways to bypass occlusion. All of the studies used the triple relationships LNAME versus L- arginine versus L-NAME + L-arginine, all together, as an indicator how NO-system may be involved. In a series of more than 80 targets investigated, L-NAME and L-arginine exhibited the opposite, but also the parallel effects. We proposed the presentation of new additional receptor(s) to resolve the matching of NO agents commonly supposed that negatively or positively affected the NO system and BPC 157 central role

table gastric pentadecapeptide BPC 157 · NO-system modulation · L-NAME · L-Arginine

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