engleski

The Role of Complete Blood Count Parameters in Patients with Colorectal Cancer

Chronic infl ammation has been linked with many cancers. It seems that easily available and usual blood infl ammatory markers might serve as a prognostic factor for overall survival and disease-free survival in patients with various cancers. Preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as well as hemoglobinemia, thrombocytosis, elevated C-reactive protein values, neutropenia and leukocytosis have been shown to aff ect overall survival and disease-free survival in patients with colorectal cancer (CRC), however, with controversial results. Complete blood count, NLR and PLR were determined in 71 patients with CRC (stages 3 and 4) after neoadjuvant chemo-radiotherapy and before surgery, treated at Hospital for Tumors in Zagreb. Statistical analysis included Mann-Whitney U test, Student’s t-test, univariate and multivariate analysis. Th e results of Mann- Whitney U test and Student’s t-test showed that neutrophil count (p=0.024), NLR (p=0.003) and PLR (p=0.007) correlated signifi cantly with overall survival. However, there was no signifi cant correlation of age, leukocyte, lymphocyte and platelet counts and hemoglobin values with overall survival of patients. Furthermore, the same tests showed that leukocyte (p=0.04), neutrophil (p=0.0014) and platelet (p=0.006) counts, NLR (p=0.0006) and PLR (p=0.0015), as well as hemoglobin values (p=0.028) correlated signifi cantly with disease-free survival. Th e results of univariate analysis showed that unlike PLR, NLR correlated with overall survival and disease-free survival (p=0.0002), although the correlation of PLR and disease-free survival almost reached signifi cance (p=0.059). Furthermore, the results of univariate analysis showed signifi cant correlation of advanced pathological TNM stage with overall survival. Th ere was no correlation of patient age and gender, tumor stage and neoadjuvant chemo- radiotherapy with overall survival and diseasefree survival. Th e results of multivariate analysis showed that NLR (cut-off value 3.27) and advanced pathological TNM stage signifi cantly correlated with disease-free survival but not with overall survival. It seems that NLR might be an accurate marker for overall survival and disease-free survival in CRC patients after neoadjuvant chemo-radiotherapy and before surgery

inflammation ; blood cell count ; colorectal neoplasms ; disease-free survival ; c-reactive protein

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