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Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-NG- nitro-L-arginine methyl ester worsening (CROSBI ID 322933)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bilić, Zdenko ; Gojković, Slaven ; Kalogjera, Luka ; Krezić, Ivan ; Malekinušić, Domagoj ; Knežević, Mario ; Sever, Marko ; Lojo, Nemir ; Kokot, Antonio ; Kasnik, Katarina et al. Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pa // Journal of physiology and pharmacology, 72 (2021), 6; 939-955. doi: 10.26402/jpp.2021.6.11

Podaci o odgovornosti

Bilić, Zdenko ; Gojković, Slaven ; Kalogjera, Luka ; Krezić, Ivan ; Malekinušić, Domagoj ; Knežević, Mario ; Sever, Marko ; Lojo, Nemir ; Kokot, Antonio ; Kasnik, Katarina ; Kralj, Tamara ; Vukojević, Jakša ; Siroglavić, Marko ; Peklić, Marina ; Drmić, Domagoj ; Milavić, Maria ; Sikirić, Sunčana ; Skorak, Ivan ; Brizić, Ivan ; Hriberski, Klaudija ; Kubat, Milovan ; Vlainić, Josipa ; Boban Blagaić, Alenka ; Tvrdeić, Ante ; Škrtić, Anita ; Seiwerth, Sven ; Sikirić, Predrag

engleski

Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-NG- nitro-L-arginine methyl ester worsening

Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged bleeding, debilitated defect large widening. Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min). Within 1 - 15 min post-injury period, with cytoprotective BPC 157 (0.01 μg), the rapidly restored vessels 'run' (vessels filled/reappeared) toward the perforated defect, and there is less bleeding, and defect contraction ; advanced perforated lesion healing (day 1) to complete healing (day 7), and less adhesions. With pantoprazole (10 mg), early (vessels (worsening), bleeding (prolongation), defect (attenuated widening)) effect means eventual lesions and adhesions severity as in controls. Ranitidine (10 mg) early effect (vessels (improvement), bleeding (less bleeding), defect (eliminated widening, defect not changed)) means final lesions attenuation, but not complete healing, less adhesions. L-NAME (5 mg) early (vessels worsening, less bleeding, attenuated defect widening) and final (lesions aggravation, more adhesions) effect, versus L-arginine (100 mg) early (vessels improvement, more bleeding, attenuated defect widening) and final (lesions attenuation, less adhesions) effect, combined few simultaneously occurring nitric oxide (NO)-system distinct processes. Finally, in the stomach tissue surrounding defect, increased malondialdehyde (MDA)- and decreased NO-values, BPC 157 reversed to the normal healthy values, and mRNA expression studies (Cox2, VEGFa, Nos1, Nos 2, Nos3, Nkap (NF- kappa-B-activating protein gene)), done at that very early post-perforation-time, indicate a way how BPC 157 may act beneficially in the perforated stomach lesion throughout NO- and prostaglandinds- system.

Pentadecapeptide BPC 157 ; nitric oxide vessels ; perforated stomach ; L-arginine ; L-NG-Nitro-L-arginine methylester ; pantoprazole ; ranitidine ; cytoprotection ; cyclooxygenase 2 ; bleeding time

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Podaci o izdanju

72 (6)

2021.

939-955

objavljeno

0867-5910

10.26402/jpp.2021.6.11

Povezanost rada

Temeljne medicinske znanosti

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