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LIN28 family in testis: control of cell renewal, maturation, fertility and aging (CROSBI ID 322689)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Krsnik, Dajana ; Marić, Tihana ; Bulić-Jakuš, Floriana ; Sinčić, Nino ; Katušić Bojanac, Ana LIN28 family in testis: control of cell renewal, maturation, fertility and aging // International journal of molecular sciences, 23 (2022), 13; 7245, 24. doi: 10.3390/ijms23137245

Podaci o odgovornosti

Krsnik, Dajana ; Marić, Tihana ; Bulić-Jakuš, Floriana ; Sinčić, Nino ; Katušić Bojanac, Ana

engleski

LIN28 family in testis: control of cell renewal, maturation, fertility and aging

Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members-LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter's syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents.

LIN28A ; LIN28B ; cancer ; infertility ; testis

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Podaci o izdanju

23 (13)

2022.

7245

24

objavljeno

1422-0067

10.3390/ijms23137245

Trošak objave rada u otvorenom pristupu

Povezanost rada

Temeljne medicinske znanosti

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