engleski

Supramolecular self-assembled peptide hydrogels Ac-L-Phe-L-Phe-L-Ala-NH2 for vaccine delivery with adjuvant activity

Adjuvants are used in order to enhance vaccine potency by improvement of the humoral and cellmediated immune response to vaccine antigens. Adjuvants of new generation often include different biocompatible nanomaterials for sustained release of antigen and at the same time have adjuvant properties themselves. Supramolecular self-assembled peptide hydrogels have a great potential for applications in bionanotechnology and it has been shown that certain peptides possess immunostimulatory activity (1). We report here the adjuvant system based on supramolecular hydrogel of a self- assembling tripeptide Ac-L-Phe-L-Phe-L-Ala-NH2 (2) and evaluated for their in vivo adjuvant activity. The results of our experiment have shown that the examined hydrogels based on Ac-Phe-Phe-AlaNH2 and tripeptides Ac-Phe-Phe--Ala-OMe and Ac-Phe-Phe- Ala-OH induce a strong specific immune response in mice compared to the antigen itself. Also, these three adjuvant formulations modulated the type of specific immunoreaction

Adjuvant ; peptide hydrogel ; immune reaction ; vaccine

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