engleski

Solvent-free mechanochemical synthesis of HostGuest Complexes with Cucurbit[n]uril

Cucurbit[n]urils (n = 5-10) are rigid host molecules with hydrophobic cavities that can bind guests in 1:1, 2:1, or 1:2 complexes and have been used previously to bind hydrophobic guests in water often with extreme binding affinities up to 7.2 x 1017 M−1 .[1-3] Solvent-free mechanochemical synthesis (ball milling) has been shown to be a useful method for the preparation of inclusion complexes with cucurbit[7]uril and adamantane and phenyl derivates as model molecules of guests.[4] Therefore, we researched various phenylenediamine derivatives and ferrocene inclusion complexes with Cucurbit[n]uril. Studies included mechanochemical formation of inclusion complex in vibrational mill. In situ monitoring of grinding reactions by Raman spectroscopy enabled direct insight into the successful formation of the HostGuest complex and the mechanochemistry of grinding.[5]. Host-guest complexation in the solidstate was studied and characterized by X-ray powder diffraction, FTIR, NMR spectroscopy, and differential scanning calorimetry.

complex ; cucurbituril ; solvent-free

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