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Application of the Alkaline Comet Assay in Biomonitoring of Medical Personnel Occupationally Exposed to Ionizing Radiation


Kopjar, Nevenka; Garaj-Vrhovac, Vera
Application of the Alkaline Comet Assay in Biomonitoring of Medical Personnel Occupationally Exposed to Ionizing Radiation // European IRPA congress 2002 : Proceedings
Firenca, 2002. str. 1-10 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
Application of the Alkaline Comet Assay in Biomonitoring of Medical Personnel Occupationally Exposed to Ionizing Radiation

Autori
Kopjar, Nevenka ; Garaj-Vrhovac, Vera

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
European IRPA congress 2002 : Proceedings / - Firenca, 2002, 1-10

Skup
European IRPA congress 2002

Mjesto i datum
Firenca, Italija, 08-11.10.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Comet assay; occupational exposure; ionizing radiation

Sažetak
The alkaline comet assay was selected as a biomarker of exposure to evaluate the ongoing exposure to ionizing radiation in medical workers occupationally exposed to ionizing radiation and corresponding non-exposed control subjects. The primary DNA damage was evaluated by measuring the extent of DNA migration in peripheral blood leukocytes. The interindividual differences in DNA damage between exposed subjects were also assessed by comparison of their dosimeter readings. It was found that medical workers who were occupationally exposed to ionizing I radiation for different periods of time showed significantly increased levels of DNA darnage compared with control subjects. There was a significant correlation between the severity of DNA damage and duration of exposure. However, no significant correlation was found between the age of all subjects and DNA damage. According to our results, the alkaline comet assay as a sensitive technique for the assessment of the DNA damage could be usefully applied in the regular health screening of workers occupationally exposed to ionizing radiation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

Napomena
Rad je objavljen i u Knjizi sažetaka sa Skupa, str. 200-200.



POVEZANOST RADA


Projekt / tema
0022020

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb