Cytokines and chemokines involved in osteoarthritis pathogenesis (CROSBI ID 321899)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Molnar, Vilim ; Matišić, Vid ; Kodvanj, Ivan ; Bjelica, Roko ; Jeleč, Željko ; Hudetz, Damir ; Rod, Eduard ; Čukelj, Fabijan ; Vrdoljak, Trpimir ; Vidović, Dinko ; Starešinić, Mario ; Sabalić, Srećko ; Dobričić, Borut ; Petrović, Tadija ; Antičević, Darko ; Borić, Igor ; Košir, Rok ; Prosenc Zmrzljak, Uršula ; Primorac, Dragan
engleski
Cytokines and chemokines involved in osteoarthritis pathogenesis
Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The pathogenesis of this degenerative process is not completely understood ; however, a low-grade inflammation leading to an imbalance between anabolic and katabolic processes is a well- established factor. The complex network of cytokines regulating these processes and cell communication has a central role in the development and progression of osteoarthritis. Concentrations of both proinflammatory and anti- inflammatory cytokines were found to be altered depending on the osteoarthritis stage and activity. In this review, we analyzed individual cytokines involved in the immune processes with an emphasis on their function in osteoarthritis.
biomarker ; chemokines ; cytokines ; inflammation ; osteoarthritis ; pathogenesis
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Podaci o izdanju
22 (17)
2021.
9208
23
objavljeno
1422-0067
10.3390/ijms22179208
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti