engleski

Antimicrobially modified continuous yarns from electrospun fibers

Common injuries of the musculoskeletal system that require surgical repair have a failure rate of up to 40%, so there is a need for the development of new materials that can be inserted in the place of the injury. In addition, infections caused by antibiotic-resistant bacteria during the hospital care cause more deaths than AIDS, tuberculosis and viral hepatitis together [1]. Therefore, there is a need for development of new antimicrobial implants containing coatings [2] active against Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA), microorganism strains resistant to antibiotics. The antimicrobial coatings with mixtures of nanoparticles are applied on the surface of materials by sol-gel process and characterized by different spectroscopic, microscopic and chromatographic methods [3]. The combination of the electro-spinning of the yarns and their surface modification can result in antimicrobial materials interesting for medical implants. Therefore, here we propose the functionalization of the continuous yarns from electrospun fibers (Figure 1) with antimicrobial coating containing antimicrobial nanoparticles by dip coating methodology. Since recent biological investigation showed that the biphasic scaffold components are noncytotoxic, and that tendon and bone cells can be grown on the cuff and block, [4] we expect that proposed combination of treatments will result in antimicrobial materials useful in hospital care.

Antimicrobially modified continuous yarns from electrospun fibers

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