engleski

IMPACT OF DISABILITY ON BODY COMPOSITION IN MULTIPLE SCLEROSIS

Multiple sclerosis (MS) is a chronic disease of the central nervous system, more prevalent in women than in men, leading to impairment of motor function and cognitive dysfunction with deterioration of body composition. Significant differences in body composition be-tween body mass index-matched men with and without MS have been reported, although this was not observed in women. According to recent research cognitive function does not correlate to body composition parameters in MS patients. Disability and inactivity varies widely between four different clinical profiles: clinically isolated syndrome, relapsing-remitting MS (RRMS), primary and secondary progressive MS. Impact on body composition has been mostly researched in RRMS. More dis-abled MS patients present with higher body fat and lower bone tissue content and density than those with milder disability. Physical inactivity in MS patients is associated with changes in body composition. Non-drug-based symptomatic treatment approach in MS encompasses physical therapy with positive effects that include symptom reduction and enhancement of mobility, however there have been contrary results on the impact of body composition. Matusik et al. found that physiotherapy had a significant impact on functional mobility and it was related to body composition. Whereas, Silveria et al. did not find a correlation between symptoms and body composition in MS patients that underwent physical activity intervention. Furthermore, pilates has not been shown to impact body composition. High intensity exercise therapy in milder patients seems to have an effect on fat mass, fat percentage and fat-free mass over time. Further research is needed to explore differences in body composition between genders and MS clinical profiles, and develop potential strategies to address changes in body composition in MS.

MULTIPLE SCLEROSIS ; BODY COMPOSITION ; DISABILITY

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