engleski

p53 and Ki-67 in proliferative skin disease

p53 protein is essential for the regulation of cell proliferation and its aberrant accumulation is usually seen in malignant tumors but, also, occurs in squamous epithelium of inflammatory skin diseases characterized by hiperproliferation. The aim of this study is to elucidate the role of the p53 tumor-suppressor protein in the pathogenesis of different hiperproliferative, non-malignant and malignant skin diseases, and association between p53 overexpression and cell proliferation.The positivity of p53 and Ki-67 protein differed significantly among the groups. Conclusions: Our findings suggest that p53 overexprression occurs widely in neoplastic and non-neoplastic skin lesions. It is associated with the cell proliferation in normal, as well as, in changed epithelium.

p53 protein; Ki-67 protein expression; cell proliferation

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