engleski

Designing opto-bioelectronic interfaces: from in- silico to in-vivo

Designing effective bioelectronic devices such as neurostimulators or recording interfaces requires a multi-disciplinary integrative approach involving experts from materials science, electrical- and bio-engineering and medical science due to the complex nature of the problem. To bridge the gaps in understanding between those fields, we propose using integrated realistic numerical models of the bioelectronic device and the biological system as a non-biased mediator and as an alternative to expensive and sometimes ethically dubious in-vivo experiments. State of the art in computing power and software development currently enables the integration of numerical 3D models of the stimulation device and the stimulation target. Such models could speed up the device development and reduce the costs involved with the repetitive invivo experiments. We will show a numerical model of an opto- bioelectronic stimulation device coupled with Hodgkin-Huxley’s numerical model of a single neuron to study the suitability of our devices for single-cell stimulation. Based on the model’s results, we will show guidelines and requirements for the successful stimulation of single cells, especially relating to the electrode material and electrochemical parameters. We will show how our simulation toolset can be applied to a more general class of bioelectronic interfaces.

bioelectronics, modeling, interface, in-silico. in-vivo

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