engleski

Antiproliferative and antibacterial activity in vitro of amidino substituted 2-naphthylbenzazoles

Taking into account that benzimidazole, benzothiazole and benzoxazole nuclei, as a part of nitrogen heterocycles, are highly-privileged building structural motifs in organic and medicinal chemistry, they played unavoidable role in the rational drug design. Among their versatile pharmacological features, the most important ones are antimicrobial, antitumor, antiviral, anti- inflammanory, antihistaminic, antioxidant, etc. On the other hand, amidines are known as important pharmacophore functional groups usually placed at the termini of the biologically active molecules. They are a structural parts of the numerous biologically active compounds and many important medical and biochemical agents. Amidine groups, usually in cationic form, could significantly contribute to the molecule/possible biological target complex stability. Herein we present the synthesis, structural characterization and biological evaluation of amidino substituted benzimidazole and benzothiazole derivatives substituted with 2- naphthyl ring. All targeted compounds have been synthesized according to the conventional methods of organic synthesis. They have been evaluated on the several human cancer cell lines for their antiproliferative activity in vitro. Additionally, all synthesized compounds have been tested against several Gram negative and Gram positive bacterial strains in vitro.

amidines, antibacterial activity, antiproliferative activity, benzimidazoles, benzothiazoles

nije evidentirano