Does COVID-19 infection acquired in different pregnancy trimester influence placental pathology? (CROSBI ID 328221)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dagelic, Andrea ; Stefanovic, Vedran ; Resic Karara, Jasminka ; Kuzmic Prusac, Ivana ; Roje, Damir ; Kosovic, Indira ; Zekic Tomas, Sandra
engleski
Does COVID-19 infection acquired in different pregnancy trimester influence placental pathology?
Objectives: To determine the morphological characteristics of the placentas from COVID-19 positive mothers in regard to the trimester of COVID-19 infection onset and low weight molecular heparin (LMWH) treatment.Methods: Placentas were collected in the period April 1st till September 1st 2021 after delivery at Department of Obstetrics and Gynecology University Hospital Split, Croatia, and sent for pathological examination. Medical history and pathology reports were used to collect the data. Pregnant women were divided based on the onset of COVID-19 infection and stratified into low molecular weight heparin (LMWH)+ or LMWH-. Depending on the data distribution, the following test were used: chi- squared test. Student's t-test, Mann-Whitney U test, ANOVA and Kruskal-Wallis test.Results: In 38% of patients the onset of COVID-19 infection was the 1st trimester of pregnancy, in 27% in the 2nd and 35% of women were infected in the 3rd trimester The fetal vascular malperfusion (FVM) occurrence was statistically significantly higher in the LMWH- group and if the onset of infection was in the 2nd trimester, while the perivillous fibrin deposition was most likely to happen if the COVID-19 infection that occured in the 1st trimester of pregnancy.Conclusions: The onset of COVID-19 infection has the influence on trophoblast damage and subsequent morphological appearance of the placenta. LMWH use in COVID positive pregnant women decreases the rate of the FVM in examined placentas.
COVID-19 ; low molecular weight heparin (LMWH) ; placenta
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Podaci o izdanju
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2022.
rani pristup (online first)
0300-5577
1619-3997
10.1515/jpm-2022-0452
Povezanost rada
Kliničke medicinske znanosti