engleski

Genome-wide signals of positive selection identified in Livestock Guardian Dogs

Livestock Guardian Dogs (LGDs, Canis familiaris) are large dogs adapted to harsh mountain environments and selected to protect grazing livestock from predators in free-ranging grazing systems. Signals of positive selection in a meta- population represented by nine LGD breeds (116 individuals) were analysed based on information from 104, 618 SNP genotypes using the extreme Runs of Homozygosity islands (eROHi) and the integrated Haplotype Score (iHS) approach. We found that 28 genomic regions (11 identified using the eROHi approach and 17 using the iHS approach) had highly significant signals for positive selection. Some of the most pronounced selection signals are associated with genes such as LRIG3, TRIP11, CNTNAP2 and EFNA5. The presented results will contribute to the understanding of the synergistic behavioural interaction of LGDs with humans and grazing animals, especially sheep and goats, and the mammals' adaptation to harsh mountain conditions, as well as to their breeding management.

Livestock Guardian Dogs ; Positive selection signals ; Adaptation ; Synergistic behavioural interaction

nije evidentirano