Impact of vaccination on the presence and severity of symptoms of hospitalised patients with an infection by the omicron variant (B.1.1.529) of the SARS-cov-2 (subvariant BA.1) (CROSBI ID 320347)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Beraud, Guillaume ; Bouetard, Laura ; Civljak, Rok ; Michon, Jocelyn ; Tulek, Necla ; Lejeune, Sophie ; Millot, Romain ; Garchet-Beaudron, Aurélie ; Lefebvre, Maeva ; Velikov, Petar ; Festou, Benjamin ; Abgrall, Sophie ; Lizatovic, Ivan Kresimir ; Baldolli, Aurélie ; Esmer, Huseyin ; Blanchi, Sophie ; Froidevaux, Gabrielle ; Kapincheva, Nikol ; Faucher, Jean-François ; Duvnjak, Mario ; Afşar, Elçin ; Švitek, Luka ; Yarimoglu, Saliha ; Yarimoglu, Rafet ; Janssen, Cécile ; Epaulard, Olivier
engleski
Impact of vaccination on the presence and severity of symptoms of hospitalised patients with an infection by the omicron variant (B.1.1.529) of the SARS-cov-2 (subvariant BA.1)
Objectives: The emergence of SARS-CoV-2 variants raised questions over the extent to which vaccines designed in 2020 have remained effective. We aimed to assess whether vaccine status was associated with the severity of Omicron SARS-CoV-2 infection in hospitalised patients. Methods: We conducted an international, multicentric, retrospective study in 14 centres (Bulgaria, Croatia, France, Turkey). We collected data on patients hospitalised ≥24 hours between 01/12/2021 and 03/03/2022, with PCR-confirmed infection at a time of exclusive Omicron circulation, with hospitalisation related or not to the infection. Patients who had received prophylaxis by monoclonal antibodies were excluded. Patients were considered fully vaccinated if they had received at least 2 injections of either mRNA and/or ChAdOx1-S, or 1 injection of Ad26.CoV2-S vaccines. Results: Among the 1215 patients (median [IQR] age 73.0 [57.0 ; 84.0] ; 51.3% males), 746 (61.4%) were fully vaccinated. In multivariate analysis, being vaccinated was associated with lower 28-day mortality (RR=0.50 [0.32-0.77]), ICU admission (R=0.40 [0.26-0.62], and oxygen requirement (RR=0.34 [0.25-0.46]), independently of age and comorbidities. When co-analysing these Omicron patients with 948 Delta patients from a study we recently conducted, Omicron infection was associated with lower 28-day mortality (RR=0.53 [0.37-0.76]), ICU admission (R=0.19 [0.12-0.28], and oxygen requirements (RR=0.50 [0.38-0.67]), independently of age, comorbidities and vaccination status. Conclusions: Originally designed vaccines have remained effective on severity of Omicron SARS-CoV-2 infection. Omicron is associated with a lower risk of severe forms, independently of vaccination and patient characteristics.
Breakthrough infection ; Omicron ; SARS-CoV-2 ; Severity ; Vaccine
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Podaci o izdanju
28 (12)
2022.
CMI 3169
9
objavljeno
1198-743X
10.1016/j.cmi.2022.12.020
Povezanost rada
Interdisciplinarne prirodne znanosti, Javno zdravstvo i zdravstvena zaštita, Temeljne medicinske znanosti