Multifunctional scaffolds based on Sr,Mg,Ag-substituted octacalcium phosphate and carboxymethyl chitosan (CROSBI ID 731503)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Ressler, Antonia ; Marić, Marina Monika ; Ivanković, Hrvoje ; Ivanković, Marica
engleski
Multifunctional scaffolds based on Sr,Mg,Ag-substituted octacalcium phosphate and carboxymethyl chitosan
One of the used approaches to improve the biological and physicochemical properties of scaffolds is ionic substitutions with key role ions. Octacalcium phosphate (OCP) is considered a precursor of biological apatite and has shown remarkable regenerative properties. In this study, Sr, Mg, Ag-substituted OCP powders were prepared by precipitation method with varying substitution content (0, 1 and 2.5 mol%). Prepared powder samples were composed of OCP and amorphous calcium phosphate, while lattice parameters of OCP changed depending on the size of Sr2+ (0.113 nm), Mg2+ (0.072 nm) and Ag+ (0.0128 nm) ions. Substitution with Sr2+ and Ag+ ions increased, while with Mg2+ ion decreased the thermal stability of OCP. Substituted OCP crystals have shown characteristic plate-like morphology with homogeneously distributed ions. To obtain multifunctional scaffolds, Sr, Mg, Ag-substituted OCP powders have been mixed to determine the synergic properties of substituents. The substituted ions enhanced protein adsorption capacity and antibacterial activity towards Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Highly porous scaffolds based on obtained powders and carboxymethyl chitosan have been prepared by the feeze-gelation technique. The scaffolds have shown a highly porous structure, with interconnected pores and high stability in simulated body conditions.
antibacterial activity ; carboxymethyl chitosan ; magnesium ; octacalcium phosphate ; silver ; strontium
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Podaci o prilogu
1-1.
2023.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
47th International Conference and Expo on Advanced Ceramics and Composites (ICACC2023)
pozvano predavanje
22.01.2023-27.01.2023
Daytona Beach, Florida, SAD