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The Impact of Long-Term Clinoptilolite Administration on the Concentration Profile of Metals in Rodent Organisms (CROSBI ID 320244)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Dolanc, Ivan ; Ferhatović Hamzić, Lejla ; Orct, Tatjana ; Micek, Vedran ; Šunić, Iva ; Jonjić, Antonija, Jurasović, Jasna ; Missoni, Saša ; Čoklo, Miran ; Kraljević Pavelić, Sandra The Impact of Long-Term Clinoptilolite Administration on the Concentration Profile of Metals in Rodent Organisms // Biology, 12 (2023), 2; 193-211. doi: 10.3390/biology12020193

Podaci o odgovornosti

Dolanc, Ivan ; Ferhatović Hamzić, Lejla ; Orct, Tatjana ; Micek, Vedran ; Šunić, Iva ; Jonjić, Antonija, Jurasović, Jasna ; Missoni, Saša ; Čoklo, Miran ; Kraljević Pavelić, Sandra

engleski

The Impact of Long-Term Clinoptilolite Administration on the Concentration Profile of Metals in Rodent Organisms

Heavy metals are dangerous systemic toxicants that can induce multiple organ damage, primarily by inducing oxidative stress and mitochondrial damage. Clinoptilolite is a highly porous natural mineral with a magnificent capacity to eliminate metals from living organisms, mainly by ion- exchange and adsorption, thus providing detoxifying, antioxidant and anti-inflammatory medicinal effects. The in vivo efficiency and safety of the oral administration of clinoptilolite in its activated forms, tribomechanically activated zeolite (TMAZ) and Panaceo-Micro-Activated (PMA) zeolite, as well as the impact on the metallic biodistribution, was examined in healthy female rats. Concentration profiles of Al, As, Cd, Co, Pb, Ni and Sr were measured in rat blood, serum, femur, liver, kidney, small and large intestine, and brain using inductively coupled plasma mass spectrometry (ICP- MS) after a 12-week administration period. Our results point to a beneficial effect of clinoptilolite materials on the concentration profile of metals in female rats supplemented with the corresponding natural clinoptilolite materials, TMAZ and PMA zeolite. The observed decrease of measured toxicants in the kidney, femur, and small and large intestine after three months of oral intake occurred concomitantly with their most likely transient release into the bloodstream (serum) indicative of a detoxification process.

heavy metals ; clinoptilolite ; ICP-MS

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Podaci o izdanju

12 (2)

2023.

193-211

objavljeno

2079-7737

10.3390/biology12020193

Povezanost rada

Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Interdisciplinarne biotehničke znanosti

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