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izvor podataka: crosbi

Heavy metals and essential metals are associated with cerebrospinal fluid biomarkers of Alzheimer's disease (CROSBI ID 320215)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Babić Leko, Mirjana ; Mihelčić, Matej ; Jurasović, Jasna ; Nikolac Perković, Matea ; Španić, Ena ; Sekovanić, Ankica ; Orct, Tatjana ; Zubčić, Klara ; Langer Horvat, Lea ; Pleić, Nikolina et al. Heavy metals and essential metals are associated with cerebrospinal fluid biomarkers of Alzheimer's disease // International journal of molecular sciences, 24 (2023), 1; 467, 28. doi: 10.3390/ijms24010467

Podaci o odgovornosti

Babić Leko, Mirjana ; Mihelčić, Matej ; Jurasović, Jasna ; Nikolac Perković, Matea ; Španić, Ena ; Sekovanić, Ankica ; Orct, Tatjana ; Zubčić, Klara ; Langer Horvat, Lea ; Pleić, Nikolina ; Kiđemet- Piskač, Spomenka ; Vogrinc, Željka ; Pivac, Nela ; Diana, Andrea ; Borovečki, Fran ; Hof, Patrick R. ; Šimić, Goran

engleski

Heavy metals and essential metals are associated with cerebrospinal fluid biomarkers of Alzheimer's disease

Various metals have been associated with the pathogenesis of Alzheimer's disease (AD), principally heavy metals that are environmental pollutants (such as As, Cd, Hg, and Pb) and essential metals whose homeostasis is disturbed in AD (such as Cu, Fe, and Zn). Although there is evidence of the involvement of these metals in AD, further research is needed on their mechanisms of toxicity. To further assess the involvement of heavy and essential metals in AD pathogenesis, we compared cerebrospinal fluid (CSF) AD biomarkers to macro- and microelements measured in CSF and plasma. We tested if macro- and microelements' concentrations (heavy metals (As, Cd, Hg, Ni, Pb, and Tl), essential metals (Na, Mg, K, Ca, Fe, Co, Mn, Cu, Zn, and Mo), essential non-metals (B, P, S, and Se), and other non-essential metals (Al, Ba, Li, and Sr)) are associated with CSF AD biomarkers that reflect pathological changes in the AD brain (amyloid β1- 42, total tau, phosphorylated tau isoforms, NFL, S100B, VILIP-1, YKL-40, PAPP-A, and albumin). We used inductively coupled plasma mass spectroscopy (ICP-MS) to determine macro- and microelements in CSF and plasma, and enzyme-linked immunosorbent assays (ELISA) to determine protein biomarkers of AD in CSF. This study included 193 participants (124 with AD, 50 with mild cognitive impairment, and 19 healthy controls). Simple correlation, as well as machine learning algorithms (redescription mining and principal component analysis (PCA)), demonstrated that levels of heavy metals (As, Cd, Hg, Ni, Pb, and Tl), essential metals (Ca, Co, Cu, Fe, Mg, Mn, Mo, Na, K, and Zn), and essential non- metals (P, S, and Se) are positively associated with CSF phosphorylated tau isoforms, VILIP-1, S100B, NFL, and YKL-40 in AD.

Alzheimer’s disease ; arsenic ; biomarker ; cadmium ; calcium ; cerebrospinal fluid ; essential metals ; heavy metals ; iron ; mercury ; zinc

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nije evidentirano

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Podaci o izdanju

24 (1)

2023.

467

28

objavljeno

1422-0067

10.3390/ijms24010467

Povezanost rada

Biologija, Kliničke medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti), Psihologija, Temeljne medicinske znanosti

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