engleski

Craniocervical dystonia induced by oxycodone- escitalopram: possible role of gene polymorphism and drug-drug interactions

Tardive dystonia (TD) is usually associated with long-term exposure to dopamine-receptor blockingagents (DRBA), but there are also nonneuroleptic compounds that are associated with TD, including antidepressants, antiepileptics, oral contraceptives, stimulants, mood stabilizers etc. Chronic pain syndromes are common in patients with depression, and clinicians frequently prescribe opioids and SSRIs together. However, coadministration of these drugs increase the risk for drug-drug interactions (Feng et al. 2017, Kotlinska-Lemieszek et al. 2015). Drug-drug- interactions-induced serotonin syndrome caused by treatment with oxycodone and SSRI is widely known (Rosebraugh et al. 2011, Karunatilake and Buckley 2006, Walter et al. 2012). We report a case of tardive craniocervical dystonia induced by coadministration of escitalopram-oxycodone.

craniocervical dystonia

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