engleski

No difference in outcomes of liver transplantation using elderly donor grafts versus young donor grafts in the setting of short cold ischemia times

Background and aims: Liver transplantation using elderly donor livers is expected to yield results that are inferior to transplantation using young donor grafts. Cold ischemia time is one of the major predictors of postoperative liver function and has a significant influence on short-term and long-term outcomes. In this study, we compared the outcomes of transplantation using young (<45 y) and elderly (>75y) liver grafts in the setting of short cold ischemia times (<8 h). Methods: A group of 87 recipients of elderly donor liver grafts was compared to a group of 124 recipients of young liver grafts. The groups were matched with regard to age, MELD score and etiology of liver disease. Both groups had mean cold ischemia times of less than 8 hours. Parameters studied included graft and patient survival rates, biochemical markers of early liver injury and function, and the incidence of postoperative complications. Results: When cold ischemia times are kept relatively short (mean<8 hours), transplantation using elderly grafts showed similar early graft function, similar graft and patient survival rates and no significant difference in the incidences of postoperative complications. Conclusions: Livers from elderly donors show similar early postoperative function, similar incidence of complications and similar long-term outcomes when compared to younger liver grafts provided that CIT are kept short.

liver transplantation, survival analysis, elderly donor

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