Multifunctional biomass-derived and N-doped carbon quantum dots – the versatile nanoparticles for ion sensing with potential biological and pharmacological activity (CROSBI ID 731058)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Šafranko, Silvija ; Jokić, Stela
engleski
Multifunctional biomass-derived and N-doped carbon quantum dots – the versatile nanoparticles for ion sensing with potential biological and pharmacological activity
The aim of this study was to prepare, characterize and investigate the potential application of carbon quantum dots (CQD) derived from Citrus clementina peel. The prepared nanoparticles by hydrothermal synthesis using citric acid and amino acids of different complexity (Ala, Arg, Asn, Gln, Glu, Gly, His, Leu, Lys, Phe, Ser i Trp) represented model systems. The samples obtained from citric acid and amino acids Ala, Arg, His, Leu, Lys, and Trp showed great properties with calculated quantum yield (QY) from QY= 12.97% - 36.43% under investigated pH=7. Hence, these amino acids were selected for the biomass-derived CQD preparation from Citrus clementina peel. The results indicated the versatility among the prepared samples regarding optical, physical and chemical properties of nanoparticles, as well as on the biological activities, compared to the model systems. Furthermore, the best-performing samples from each series of synthesis were extensively studied regarding chemical (solubility, EDS), physical (AFM, FTIR, PXRD), optical (spectrofluorimetry, UV-Vis spectroscopy), biological and pharmacological properties. The biological activities of prepared samples were investigated by spectrophotometric methods of antiradical activity (DPPH method), inhibition of protein denaturation (bovine serum albumin and egg albumin), and biocompatibility/cytotoxicity was investigated on tumor cell lines (HeLa, NCI-H385, CaCo-2, D54). The samples were also utilized as fluorescent nanoprobe for selective and sensitive detection of Fe3+ ions and developed models were tested for the Fe3+ ion detection in real well- water samples. This research could be a good example of sustainable biomass waste utilization with potential for biomedical analysis and ion sensing applications.
carbon quantum dots ; biomass utilization ; sensors ; biomedical application
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Podaci o prilogu
30-30.
2023.
objavljeno
10.0.55.152/syrptbrs.2023.30
Podaci o matičnoj publikaciji
V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science - Book of Abstracts
Varga, Patricia ; Szalai, Boglárka ; Uhljar, Luca Éva
Segedin, Mađarska:
Podaci o skupu
V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science
predavanje
18.01.2023-20.01.2023
Szeged, Mađarska
Povezanost rada
Farmacija, Interdisciplinarne prirodne znanosti, Kemija