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Synthesis of Glycine and Phenylalanine Containing Cyclopeptides and their Anion Binding Properties in Acetonitrile (CROSBI ID 730562)

Neobjavljeno sudjelovanje sa skupa | neobjavljeni prilog sa skupa | međunarodna recenzija

Duvnjak, Mirko ; Talajić, Gregor ; Modrušan, Matija ; Petrović Hađar, Emilija ; Horvat, Gordan ; Cindro, Nikola ; Tomišić, Vladislav Synthesis of Glycine and Phenylalanine Containing Cyclopeptides and their Anion Binding Properties in Acetonitrile // 5. simpozij supramolekulske kemije Zagreb, Hrvatska, 08.12.2022-08.12.2022

Podaci o odgovornosti

Duvnjak, Mirko ; Talajić, Gregor ; Modrušan, Matija ; Petrović Hađar, Emilija ; Horvat, Gordan ; Cindro, Nikola ; Tomišić, Vladislav

engleski

Synthesis of Glycine and Phenylalanine Containing Cyclopeptides and their Anion Binding Properties in Acetonitrile

In the last few decades cyclic peptides have become compounds of interest due to their potential biological activity as well as their ability to act as molecular recepors.1-2 Cyclic peptides are especially attractive as biologically active compounds due to their increased bioavailability and metabolic stability. To gain further insight into the reactivity and anion binding properties of cyclopeptides we synthesized three peptides, tetrapeptide Phe-Phe-Gly-Gly 1, pentapeptide Phe-Phe-Gly-Gly-Phe 2 and hexapeptide Phe-Phe-Gly-Gly-Phe-Phe 3 using solution-based synthesis. The cyclization of this linear oligopeptides was then explored using a chloride- assisted macrocyclization reaction recently developed in our group3 enabling the synthesis of C2 and C3 while the tetrapeptide 1 failed to cyclize. The complexation affinity of C2 and C3 towards both cations and anions in acetonitrile was studied using fluorescence spectroscopy.

cyclopeptide ; anion binding ; acetonitrile

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Podaci o prilogu

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Podaci o skupu

5. simpozij supramolekulske kemije

poster

08.12.2022-08.12.2022

Zagreb, Hrvatska

Povezanost rada

Kemija