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izvor podataka: crosbi

Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer (CROSBI ID 318979)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ivković, Irena ; Limani, Zgjim ; Jakovčević, Antonia ; Huić, Dražen ; Prgomet, Drago Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer // Biomedicines, 10 (2022), 12; 3178, 11. doi: 10.3390/biomedicines10123178

Podaci o odgovornosti

Ivković, Irena ; Limani, Zgjim ; Jakovčević, Antonia ; Huić, Dražen ; Prgomet, Drago

engleski

Role of Matrix Metalloproteinases and Their Inhibitors in Locally Invasive Papillary Thyroid Cancer

Locally invasive papillary thyroid carcinoma (PTC) protrudes beyond the thyroid capsule and invades local structures. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are implicated in local invasion and metastasis in PTC. The aim of our study was to determine expression levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 in tissue specimens of invasive and noninvasive PTC. Our hypothesis was that expression levels of these biomarkers correlate with the development of locally invasive PTC. In our single- center study we retrospectively investigated MMP and TIMP expression levels in 50 samples of thyroid tissue diagnosed as locally invasive papillary carcinoma (study group) and 30 samples of thyroid tissue diagnosed as non-invasive, non-metastatic papillary carcinoma (control group). Tissue specimens were immunohistochemically stained with primary monoclonal antibodies against MMP-1, MMP- 2, MMP-9, TIMP-1, and TIMP-2. When correlating expression levels of MMPs and TIMPs in thyroid tissue, statistically significant differences were found for MMP-1 and TIMP-1 expression (p < 0.001 ; Mann– Whitney U test) with the highest levels of expression in the invasive PTC group. Although expression of MMP-9 and TIMP-2 was higher in invasive PTC, the differences were not statistically significant. Elevated expression of MMP-1andTIMP-1in tumor tissue can predict invasiveness for PTC.

matrix metalloproteinase ; MMP-1 ; MMP-2 ; MMP-9 ; TIMP-1 ; TIMP-2 ; papillary invasive carcinoma ; thyroid gland

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Podaci o izdanju

10 (12)

2022.

3178

11

objavljeno

2227-9059

10.3390/biomedicines10123178

Povezanost rada

nije evidentirano

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