engleski

The complexity of brain sphingomyelin

Brain SM, found in high concentrations in myelin, is a mixture of SM molecules with different lengths of hydrocarbon chains, which makes its characterization challenging. In addition, the effect of changing acyl chain length on the physical behavior of SM remains poorly understood.1By using the fluorescent probe Laurdan (L) for fluorescence measurements, its response and influence on thermal changes in the SM lipid bilayer will be observed. Besides using fluorescence spectroscopy, the analysis of thermotropic behavior of brain SM multilamellar liposomes, also includes differential scanning calorimetry (DSC) and temperature-dependent UV/Vis spectroscopy with the addition of using appropriate chemometric tools.

Sphingomyelin ; Spectroscopy ; Laurdan

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