Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population (CROSBI ID 317923)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Božina, Tamara ; Ganoci, Lana ; Karačić, Ena ; Šimičević, Livija ; Vrkić-Kirhmajer, Majda ; Klarica- Domjanović, Iva ; Križ, Tena ; Sertić, Zrinka ; Božina, Nada ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population // Annals of human biology, (2022), 1-9; 36382878, 9. doi: 10.1080/03014460.2022.2140826

Podaci o odgovornosti

Božina, Tamara ; Ganoci, Lana ; Karačić, Ena ; Šimičević, Livija ; Vrkić-Kirhmajer, Majda ; Klarica- Domjanović, Iva ; Križ, Tena ; Sertić, Zrinka ; Božina, Nada

engleski

ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population

Background: Organic anion-transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs. Genetic polymorphisms of these transporters have effect on transporter activity. There is significant interethnic variability in the frequency of allele variants. Aim: To determined allele and genotype frequencies of ABCG2 and SLCO1B1 genes in Croatian populations of European descent. Subjects and methods: A total of 905 subjects (482 women) were included. Genotyping for ABCG2 c.421C > A (rs2231142) and for SLCO1B1 c.521T > C (rs4149056), was performed by real-time polymerase chain reaction (PCR) using TaqMan® DME Genotyping Assays. Results: For ABCG2 c.421C > A, the frequency of CC, CA and AA genotypes was 81.4%, 17.8% and 0.8% respectively. The frequency of variant ABCG2 421 A allele was 9.7%. For SLCO1B1 c.521T > C, the frequency of TT, TC and CC genotypes was 61.7%, 34.8% and 3.5% respectively. The frequency of variant SLCO1B1 521 C allele was 20.9%. Conclusion: The frequency of the ABCG2 and SLCO1B1 allelic variants and genotypes in the Croatian population is in accordance with other European populations. Pharmacogenetic analysis can serve to individualise drug therapy and minimise the risk of developing adverse drug reactions

ABCG2 ; Croatian population ; SLCO1B1 ; drug transporters ; gene polymorphism

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

(1-9)

2022.

36382878

9

objavljeno

0301-4460

1464-5033

10.1080/03014460.2022.2140826

Povezanost rada

nije evidentirano

Poveznice
Indeksiranost