The Chloroquine Story in the First Year of the COVID-19 Pandemic (CROSBI ID 317909)
Prilog u časopisu | pregledni rad (znanstveni)
Podaci o odgovornosti
Hunić, Mateja ; Teparić, Renata ; Kovačević, Monika ; Barišić, Lidija
engleski
The Chloroquine Story in the First Year of the COVID-19 Pandemic
The emergence of COVID-19 has caused worldwide concern due to its high infectivity and mortality. Research groups around the world have prioritised drug development against COVID-19. Repurposing of already approved drugs, including the antimalarial drug chloroquine, has attracted considerable attention. The aim of this article is to (i) provide an overview of the recent chemical methods used to synthesise chloroquine and hydroxychloroquine, and (ii) provide insight into the data collected in 2020 on their efficacy against COVID-19. Unfortunately, the promising early results have not been confirmed and a clear and unambiguous conclusion on their clinical efficacy has not yet been drawn.
Chemical synthesis ; chloroquine ; COVID-19 ; hydroxychloroquine ; SARS-CoV-2
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Podaci o izdanju
71
2022.
473-484
objavljeno
0022-9830
1334-9090
10.15255/KUI.2021.072
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Biotehnologija, Interdisciplinarne prirodne znanosti, Kemija