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Evaluation of corticospinal tract integrity with navigated TMS corresponds to MRI and the EDSS classifications in multiple sclerosis (CROSBI ID 729326)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Rogić Vidaković, Maja ; Ćurković Katić, Ana ; Pavelin, Sanda ; Bralić, Antonia ; Mikac, Una ; Šoda, Joško ; Jerković, Ana ; Mastelić, Angela ; Dolić, Krešimir ; Markotić, Anita et al. Evaluation of corticospinal tract integrity with navigated TMS corresponds to MRI and the EDSS classifications in multiple sclerosis // Book of abstracts - 12th International Symposium on nTMS in Neurosurgery and Neuromodulation. Berlin: Charité - Universitätsmedizin Berlin, 2022. str. 2-2

Podaci o odgovornosti

Rogić Vidaković, Maja ; Ćurković Katić, Ana ; Pavelin, Sanda ; Bralić, Antonia ; Mikac, Una ; Šoda, Joško ; Jerković, Ana ; Mastelić, Angela ; Dolić, Krešimir ; Markotić, Anita ; Režić Mužinić, Nikolina

engleski

Evaluation of corticospinal tract integrity with navigated TMS corresponds to MRI and the EDSS classifications in multiple sclerosis

Background: Examining the integrity of the corticospinal tract by navigated TMS could help in understanding the neurophysiological correlates of multiple sclerosis (MS) symptoms. Objective: To investigate MEP measures of corticospinal tract integrity with navigated TMS and its correspondence with neurological (EDSS) and neuro- radiological (MRI) classifications in people with relapsing-remitting MS (pwMS). Methods: In a cross-sectional study, MEP measures of corticospinal excitability (RMT, MEP latency, MEP amplitude), clinical disease-related (EDSS), and MRI lesion data were collected in 23 pwMS receiving teriflunomide and compared to non- clinical samples. Results: PwMS subjects differed from non-clinical samples in MEP latency for upper and lower extremity muscles. PwMS with altered TMS finding (prolonged MEP latency or absent MEP), compared to pwMS with neat TMS finding, had higher EDSS score [Median = 3.5(range 0-4) vs. 0.5(0- 2.5)] and EDSS functional pyramidal score [Median = 3.0(0-3.5) vs. 0.5(0-2)]. RMT intensity for mapping representations for lower extremity muscles was predictive for EDSS functional pyramidal scores. Overall, TMS findings classified pwMS as the same as EDSS in 70-83% of cases and were similar or more successful than MRI, which corresponded to EDSS in 57- 65% of cases. PwMS with altered TMS findings differed from those with neat TMS finding on the total number of lesions in the brain corticospinal and in cervical corticospinal tract. Conclusions: The correspondence of TMS with MRI, and EDSS classifications implies the clinical utility of navigated TMS in assessing corticospinal tract integrity in pwMS.

multiple sclerosis, transcranial magnetic stimulation, motor evoked potential, magnetic resonance imaging, EDSS

In the abstract book: Page 46, A-103

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Podaci o prilogu

2-2.

2022.

objavljeno

Podaci o matičnoj publikaciji

Book of abstracts - 12th International Symposium on nTMS in Neurosurgery and Neuromodulation

Berlin: Charité - Universitätsmedizin Berlin

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Podaci o skupu

12th International Symposium on nTMS in Neurosurgery and Neuromodulation

predavanje

16.12.2022-17.12.2022

Berlin, Njemačka

Povezanost rada

Kliničke medicinske znanosti, Temeljne medicinske znanosti