Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention (CROSBI ID 317787)
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Podaci o odgovornosti
Wang, Zhe ; Emmerich, Andrew ; Pillon, Nicolas J. ; Moore, Tim ; Hemerich, Daiane ; Cornelis, Marilyn C. ; Mazzaferro, Eugenia ; Broos, Siacia ; Ahluwalia, Tarunveer S. ; Bartz, Traci M. ; Bentley, Amy R. ; Bielak, Lawrence F. ; Chong, Mike ; Chu, Audrey Y. ; Berry, Diane ; Dorajoo, Rajkumar ; Dueker, Nicole D. ; Kasbohm, Elisa ; Feenstra, Bjarke ; Feitosa, Mary F. ; Gieger, Christian ; Graff, Mariaelisa ; Hall, Leanne M. ; Haller, Toomas ; Hartwig, Fernando P. ; Hillis, David A. ; Huikari, Ville ; Heard-Costa, Nancy ; Holzapfel, Christina ; Jackson, Anne U. ; Johansson, Asa ; Jorgensen, Anja Moltke ; Kaakinen, Marika A. ; Karlsson, Robert ; Kerr, Kathleen F. ; Kim, Boram ; Koolhaas, Chantal M. ; Kutalik, Zoltan ; Lagou, Vasiliki ; Lind, Penelope A. ; Lorentzon, Mattias ; Lyytikainen, Leo-Pekka ; Mangino, Massimo ; Metzendorf, Christoph ; Monroe, Kristine R. ; Pacolet, Alexander ; Perusse, Louis ; Pool, Rene ; Richmond, Rebecca C. ; Rivera, Natalia, V ; Robiou- Du-Pont, Sebastien ; Schraut, Katharina E. ; Schulz, Christina-Alexandra ; Stringham, Heather M. ; Tanaka, Toshiko ; Teumer, Alexander ; Turman, Constance ; Van der Most, Peter J. ; Vanmunster, Mathias ; Van Rooij, Frank J. A. ; Van Vliet- Ostaptchouk, Jana V. ; Zhang, Xiaoshuai ; Zhao, Jing-Hua ; Zhao, Wei ; Balkhiyarova, Zhanna ; Balslev-Harder, Marie N. ; Baumeister, Sebastian E. ; Beilby, John ; Blangero, John ; Boomsma, Dorret, I ; Brage, Soren ; Braund, Peter S. ; Brody, Jennifer A. ; Bruinenberg, Marcel ; Ekelund, Ulf ; Liu, Ching- Ti ; Cole, John W. ; Collins, Francis S. ; Cupples, L. Adrienne ; Esko, Tonu ; Enroth, Stefan ; Faul, Jessica D. ; Fernandez-Rhodes, Lindsay ; Fohner, Alison E. ; Franco, Oscar H. ; Galesloot, Tessel E. ; Gordon, Scott D. ; Grarup, Niels ; Hartman, Catharina A. ; Heiss, Gerardo ; Hui, Jennie ; Illig, Thomas ; Jago, Russell ; James, Alan ; Joshi, Peter K. ; Jung, Taeyeong ; Kahonen, Mika ; Kilpelainen, Tuomas O. ; Koh, Woon-Puay ; Kolčić, Ivana ; Kraft, Peter P. ; Kuusisto, Johanna ; Launer, Lenore J. ; Li, Aihua ; Linneberg, Allan ; Luan, Jian'An ; Vidal, Pedro Marques ; Medland, Sarah E. ; Milaneschi, Yuri ; Moscati, Arden ; Musk, Bill ; Nelson, Christopher P. ; Nolte, Ilja M. ; Pedersen, Nancy L. ; Peters, Annette ; Peyser, Patricia A. ; Power, Christine ; Raitakari, Olli T. ; Reedik, Magi ; Reiner, Alex P. ; Ridker, Paul M. ; Rudan, Igor ; Ryan, Kathy ; Sarzynski, Mark A. ; Scott, Laura J. ; Scott, Robert A. ; Sidney, Stephen ; Siggeirsdottir, Kristin ; Smith, Albert, V ; Smith, Jennifer A. ; Sonestedt, Emily ; Strom, Marin ; Tai, E. Shyong ; Teo, Koon K. ; Thorand, Barbara ; Toenjes, Anke ; Tremblay, Angelo ; Uitterlinden, Andre G. ; Vangipurapu, Jagadish ; Van Schoor, Natasja ; Volker, Uwe ; Willemsen, Gonneke ; Williams, Kayleen ; Wong, Quenna ; Xu, Huichun ; Young, Kristin L. ; Yuan, Jian Min ; Zillikens, M. Carola ; Zonderman, Alan B. ; Ameur, Adam ; Bandinelli, Stefania ; Bis, Joshua C. ; Boehnke, Michael ; Bouchard, Claude ; Chasman, Daniel, I ; Smith, George Davey ; De Geus, Eco J. C. ; Deldicque, Louise ; Dorr, Marcus ; Evans, Michele K. ; Ferrucci, Luigi ; Fornage, Myriam ; Fox, Caroline ; Garland, Theodore, Jr. ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Hansen, Torben ; Hayward, Caroline ; Horta, Bernardo L. ; Hypponen, Elina ; Jarvelin, Marjo- Riitta ; Johnson, W. Craig ; Kardia, Sharon L. R. ; Kiemeney, Lambertus A. ; Laakso, Markku ; Langenberg, Claudia ; Lehtimaki, Terho ; Le Marchand, Loic ; Magnusson, Patrik K. E. ; Martin, Nicholas G. ; Melbye, Mads ; Metspalu, Andres ; Meyre, David ; North, Kari E. ; Ohlsson, Claes ; Oldehinkel, Albertine J. ; Orho-Melander, Marju ; Pare, Guillaume ; Park, Taesung ; Pedersen, Oluf ; Penninx, Brenda W. J. H. ; Pers, Tune H. ; Polašek, Ozren ; Prokopenko, Inga ; Rotimi, Charles N. ; Samani, Nilesh J. ; Sim, Xueling ; Snieder, Harold ; Sorensen, Thorkild I. A. ; Spector, Tim D. ; Timpson, Nicholas J. ; Van Dam, Rob M. ; Van der Velde, Nathalie ; Van Duijn, Cornelia M. ; Vollenweider, Peter ; Volzke, Henry ; Voortman, Trudy ; Waeber, Gerard ; Wareham, Nicholas J. ; Weir, David R. ; Wichmann, Heinz-Erich ; Wilson, James F. ; Hevener, Andrea L. ; Krook, Anna ; Zierath, Juleen R. ; Thomis, Martine A., I ; Loos, Ruth J. F. ; Den Hoed, Marcel
Lifelines Cohort Study
engleski
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703, 901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to- vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise- induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.
APOLIPOPROTEIN-E GENOTYPE ; LD SCORE REGRESSION ; GENE-EXPRESSION ; EXERCISE ; COMPLEX ; PERFORMANCE ; GWAS ; HERITABILITY ; MORTALITY ; FITNESS
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Podaci o izdanju
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Temeljne medicinske znanosti
