engleski

Nanocomposite hydrogel based on self-assembly of amino acid derivatives and poly(vinyl alcohol) for biomedical applications

Supramolecular self-organizing functional materials possess specific physical and biological properties that can in some cases be controlled by external stimuli (temperature, pH, UV radiation). They are recognized as an excellent platform for application in various fields, including sensor development, biomaterials, tissue engineering and drug delivery systems. Hydrogels are biocompatible, biodegradable and non-toxic materials that are suitable for biomedical use. Combining supramolecular organizations with various inorganic or organic compounds, nanocomposite materials with improved physical and biological properties are formed. Self organizations of low molecular weight organic molecules (LMWG) based on small peptides are well described in the literature and their biocompatibility has already been shown. In the framework of this work 4-picolylamide derivatives of L-phenylalanine, L-phenylglycine and L- tryptophan were synthesized and characterized. These amino acid derivatives have been tested for their gelling properties before and after the addition of polymers of poly (ethylene glycol) (PEG) and poly (vinyl alcohol) (PVA). In the form of hydrochlorides they showed good hydrogelator properties. Gels of 4-picolylamide amino acid LMWGs were characterized by spectroscopic and microscopic methods. 4-picolylamide derivative of L-phenylglycine·HCl with the addition of PVA showed the best gelling properties. Preliminary testing of the release of doxorubicin from the gel with the addition of PVA and without PVA has been tested. The results indicate that PVA affects the gelling of 4-picolylamide derivative, accelerating it and reducing the critical concentration of the gelator while doxorubicin is released more rapidly from the gel containing PVA.

Nanocomposite hydrogel based on self-assembly of amino acid derivatives and poly(vinyl alcohol) for biomedical applications

nije evidentirano