engleski

Host-Guest Interaction Between Nabumetone and Cucurbit[7]uril in Aqueous Solutions

Despite the rapid developments in modern medicine, the pharmaceutical field still faces many challenges. The biggest of these is that the majority of existing drugs belong to the class II drugs (low solubility, high permeability) according to the Biopharmaceutics Classification System (BCS). The encapsulation of drug molecules within macrocyclic molecular containers, using supramolecular noncovalent interactions in aqueous solution, is a method of improving their bioavailability and bioactivity. Cucurbit[n]urils (CB[n] = 5-8, 10, 13-15) are a family of macrocyclic molecules with remarkable host-guest chemistry in water.1 They consist of n glycoluril units bridged by 2n methylene units forming a macrocycle with a hydrophobic cavity accessible through two identical portals. CBs have been shown to form host-guest complexes with a variety of organic and inorganic small molecules. Encapsulation is favored by hydrophobic effects within the cucurbituril cavity and further stabilized by hydrogen bonding or ion-dipole interactions with the cucurbituril portal. Specific advantages of using CBs for encapsulation of drug molecules include improved stability and solubility of the drug, controlled or triggered release, induction of pKa shifts of the drug, and use as an antidote. The CB[7] has received the most attention of the CB[n] family due to its superior solubility in water. Nabumetone, is a nonsteroidal anti-inflammatory prodrug with extremely low water solubility, which is the reason for its limited bioavailability. It is used to treat pain and inflammation associated with rheumatoid arthritis and osteoarthritis.2 In this presentation, our experimental results of complexation of NAB with CB[7] in aqueous solution will be presented.

Nabumeton, Kukurbiturili

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