Schiff base derivatives as potential acetylcholinesterase inhibitors - an In vitro study (CROSBI ID 728773)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Šubarić, Domagoj ; Komar, Mario ; Karnaš, Maja ; Bešlo, Drago ; Rastija, Vesna
engleski
Schiff base derivatives as potential acetylcholinesterase inhibitors - an In vitro study
Schiff base derivatives were synthesized by utilizing the green chemistry methods such as microwave-assisted, ultrasound-assisted and mechanochemical synthesis. [1] Acetylcholinesterase inhibitors are widely recognised as potential drugs for treating symptoms of the Alzheimer's disease. Inhibitory properties of AChE inhibitors have been used for the developmet of active compounds in plant protection treatments. Twenty-four Schiff base derivatives were tested as potential acetylcholinesterase inhibitors. In vitro experiment has been conducted on a 96-well microplate UV-Vis reader by utilizing the modified Elmann's method. [2] Absorbance readings were obtained by measuring at the wavelenght of 412 nm. Donepezil was used as a standard acetylcholinesterase inhibitor. The highest percentage of inhibition was obtained with the compound 10 (Fig. 1), 34.58%, while the lowest inhibition percentage was obtained with compound 26 (3.88%).
Schiff base ; acetylcholinesterase ; inhibition
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Podaci o prilogu
125-125.
2022.
objavljeno
Podaci o matičnoj publikaciji
19th Ružička Days Today science – tomorrow industry, Book of Abstracts
Podaci o skupu
19th Ružička Days ; Today Science - Tomorrow Industry
poster
21.09.2022-23.09.2022
Vukovar, Hrvatska