Stable methylation loci are associated with systolic blood pressure in a Croatian island population (CROSBI ID 317301)
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Podaci o odgovornosti
Sprague, Alexandar C ; Niu, Liang ; Jandarov, Rooman ; Zhang, Xiang ; Zhang, Ge ; Chen, Aimin ; Šarac, Jelena ; Čoklo, Miran ; Missoni, Saša ; Rudan, Pavao ; Langevin, Scott M. ; Deka, Ranjan
engleski
Stable methylation loci are associated with systolic blood pressure in a Croatian island population
Background: The objective was to identify stable and dynamic DNA methylation loci associated with cardiometabolic traits among an adult population from the Croatian island of Hvar. Materials & methods: An epigenome-wide association study was conducted using peripheral blood longitudinally collected at two time points 10 years apart via Infinium MethylationEPIC beadarray (n = 112). Stable and dynamic loci were identified using linear mixed models. Associations between cardiometabolic traits and loci were assessed using linear models. Results: 22 CpG loci were significantly associated with systolic blood pressure. Twenty were stable and two were dynamic. Conclusion: Multiple genes may be involved in the determination of systolic blood pressure level via stable epigenetic programming, potentially established earlier in life.
850K ; blood ; cardiometabolic ; epigenetics ; epigenome-wide ; epigenomics ; EWAS ; pressure ; SBP ; systolic
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Podaci o izdanju
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Etnologija i antropologija