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Effects of Dichlorvos and Dexamethasone Treatment on Buthyrylcholinesterase, Serum Lipids, and Lipoproteins in Rats


Lucić, Ana; Bradamante, Vlasta; Domijan, Ana-Marija; Fuchs, Radovan; Peraica, Maja; Radić, Božica; Lojkić, Mirko
Effects of Dichlorvos and Dexamethasone Treatment on Buthyrylcholinesterase, Serum Lipids, and Lipoproteins in Rats // Toxicology Letters / Dekant, W. (ur.).
Amsterdam: Elsevier, 2002. str. S86-S87 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Effects of Dichlorvos and Dexamethasone Treatment on Buthyrylcholinesterase, Serum Lipids, and Lipoproteins in Rats

Autori
Lucić, Ana ; Bradamante, Vlasta ; Domijan, Ana-Marija ; Fuchs, Radovan ; Peraica, Maja ; Radić, Božica ; Lojkić, Mirko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Toxicology Letters / Dekant, W. - Amsterdam : Elsevier, 2002, S86-S87

Skup
Eurotox 2002

Mjesto i datum
Budimpešta, Mađarska, 15-18.09.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BuChE; DDVP; HDL-kolesterol; LDL- kolesterol; ukupni kolesterol; trigliceridi
(Brain; heart; liver; plasma; protein synthesis; rat; white adipose tissue)

Sažetak
The aim of the present study was to elucidate relationship between buthyrylcholinesterase (BuChE) and individual lipids in rat plasma, using compounds which affect BuChE activity. Organophosphate dichlorvos (DDVP) ireversibly and directly inhibited the active centre of enzyme, whereas glucocorticoide dexamethasone (DM) did it indirectly in the liver cells trough transcriptional mechanism. The effect of treatment with DDVP (8.0 mg/kg) and DM (0.4 mg/kg) administered intraperitoneally at single and multiple dose on plasma BuChE activity and on the concentrations of serum lipids and lipoproteins were studied in male Wistar rats. Enzyme activity and the serum level of the lipids were determined 4., 7., and 18. day after 1, 2, and 3 DDVP administration and 4., 8., and 18. day after 2, 4 and 5 DM administration. Lower BuChE activity (20-60 % of control activity) in the rat plasma was accompanied by a significant increase in trigliceride (60-200 % p< 0.05), total cholesterol (20-40 % p< 0.05) and HDL cholesterol (20-35 % p< 0.05) whereas LDL cholesterol significantly dropped (40 % p< 0.05), regardless of the inhibitor. According to these results which showed a direct relationship between BuChE activity and the concentrations of lipid fractions it is supposed that changes in lipid metabolism is initially due to the action of DDVP or DM on enzyme activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA


Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Hrvatski veterinarski institut, Zagreb,
Medicinski fakultet, Zagreb