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Therapeutic Perspectives of IL1 Family Members in Liver Diseases: An Update (CROSBI ID 316894)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Ćurčić, Ines Bilić ; Kizivat, Tomislav ; Petrović, Ana ; Smolić, Robert ; Tabll, Ashraf ; Wu, George Y. ; Smolić, Martina Therapeutic Perspectives of IL1 Family Members in Liver Diseases: An Update // Journal of clinical and translational hepatology, 10 (2022), 6; 1186-1193. doi: 10.14218/jcth.2021.00501

Podaci o odgovornosti

Ćurčić, Ines Bilić ; Kizivat, Tomislav ; Petrović, Ana ; Smolić, Robert ; Tabll, Ashraf ; Wu, George Y. ; Smolić, Martina

engleski

Therapeutic Perspectives of IL1 Family Members in Liver Diseases: An Update

Interleukin (IL) 1 superfamily members are a cornerstone of a variety of inflammatory processes occurring in various organs including the liver. Progression of acute and chronic liver diseases regardless of etiology depends on the stage of hepatocyte damage, the release of inflammatory cytokines and disturbances in gut microbiota. IL1 cytokines and receptors can have pro- or anti- inflammatory roles, even dual functionalities conditioned by the microenvironment. Developing novel therapeutic strategies to block the IL1/IL1R signaling pathways seems like a reasonable option. This mode of action is now exploited by anakinra and canakinumab, which are used to treat different inflammatory illnesses, and studies in liver diseases are on the way. In this mini review, we have focused on the IL1 superfamily members, given their crucial role in liver inflammation diseases, specifically discussing their potential role in developing new treatment strategies.

ALCOHOLIC STEATOHEPATITIS ; INFLAMMASOME ACTIVATION ; COLORECTAL-CANCER ; DANGER SIGNALS ; IMMUNE CELLS ; URIC-ACID ; IL-33 ; HEPATITIS ; INTERLEUKIN-1 ; INJURY

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Podaci o izdanju

10 (6)

2022.

1186-1193

objavljeno

2225-0719

2310-8819

10.14218/jcth.2021.00501

Povezanost rada

Kliničke medicinske znanosti, Temeljne medicinske znanosti

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