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Pregled bibliografske jedinice broj: 1233155

Repetitive mild traumatic brain injury in TDP-43 transgenic mice: learning performance and some inflammation and stress parameters in the hippocampi


Pilipović, Kristina; Rajič Bumber, Jelena; Janković, Tamara; Gržeta, Nika; Križ, Jasna; Župan, Gordana
Repetitive mild traumatic brain injury in TDP-43 transgenic mice: learning performance and some inflammation and stress parameters in the hippocampi // EPHAR 2021
Prag, Češka: EPHAR, 2021. str. 1-1 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Repetitive mild traumatic brain injury in TDP-43 transgenic mice: learning performance and some inflammation and stress parameters in the hippocampi

Autori
Pilipović, Kristina ; Rajič Bumber, Jelena ; Janković, Tamara ; Gržeta, Nika ; Križ, Jasna ; Župan, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EPHAR 2021 / - Prag, Češka : EPHAR, 2021, 1-1

Skup
8th European Congress of Pharmacology 2021 (EPHAR 2021)

Mjesto i datum
Prag, Češka, 06-08.12.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
brain injuries ; traumatic ; hippocampus ; mice ; TDP-43 proteinopathies

Sažetak
Repetitive mild traumatic brain injury (rmTBI) has been connected with cognitive and behavioral deficits as well as progressive neurodegenerative diseases, in some of which TAR DNA-binding protein 43 (TDP-43) dysregulation has been identified. With the aim to research different therapeutic approaches for the mentioned disturbances and diseases in the future, in this study we investigated the effects of repeated concussions on the learning ability and the hippocampal expression of some markers of brain inflammation and stress in mice overexpressing mutant TDP-43, during the first week following rmTBI. Animals were subjected to mild traumas twice daily, 6 hours apart, during 5 days. One day after the final injury/sham procedure, mice were tested on the passive avoidance apparatus. Animals were sacrificed at 1, 3 or 7 days after the last trauma/sham procedure and their hippocampi were prepared for the analyses. We found no significant effect of rmTBI on the learning performance of TDP-43 transgenic mice. In the injured mice sacrificed at day 1 following rmTBI, we detected increased hippocampal expression of COX-2 while the levels of iNOS, HSP70 and cytoplasmic NFκB expressions were unaffected. This research has been fully supported by the Croatian Science Foundation grant IP-2016-06-4602 to GŽ.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-4602 - Blaga repetitivna traumatska ozljeda mozga: model za istraživanje neuropatologije i neuroupale posredovane s TDP-43 (TDP-43repTBI) (Župan, Gordana, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka


Citiraj ovu publikaciju:

Pilipović, Kristina; Rajič Bumber, Jelena; Janković, Tamara; Gržeta, Nika; Križ, Jasna; Župan, Gordana
Repetitive mild traumatic brain injury in TDP-43 transgenic mice: learning performance and some inflammation and stress parameters in the hippocampi // EPHAR 2021
Prag, Češka: EPHAR, 2021. str. 1-1 (poster, međunarodna recenzija, sažetak, znanstveni)
Pilipović, K., Rajič Bumber, J., Janković, T., Gržeta, N., Križ, J. & Župan, G. (2021) Repetitive mild traumatic brain injury in TDP-43 transgenic mice: learning performance and some inflammation and stress parameters in the hippocampi. U: EPHAR 2021.
@article{article, author = {Pilipovi\'{c}, Kristina and Raji\v{c} Bumber, Jelena and Jankovi\'{c}, Tamara and Gr\v{z}eta, Nika and Kri\v{z}, Jasna and \v{Z}upan, Gordana}, year = {2021}, pages = {1-1}, keywords = {brain injuries, traumatic, hippocampus, mice, TDP-43 proteinopathies}, title = {Repetitive mild traumatic brain injury in TDP-43 transgenic mice: learning performance and some inflammation and stress parameters in the hippocampi}, keyword = {brain injuries, traumatic, hippocampus, mice, TDP-43 proteinopathies}, publisher = {EPHAR}, publisherplace = {Prag, \v{C}e\v{s}ka} }
@article{article, author = {Pilipovi\'{c}, Kristina and Raji\v{c} Bumber, Jelena and Jankovi\'{c}, Tamara and Gr\v{z}eta, Nika and Kri\v{z}, Jasna and \v{Z}upan, Gordana}, year = {2021}, pages = {1-1}, keywords = {brain injuries, traumatic, hippocampus, mice, TDP-43 proteinopathies}, title = {Repetitive mild traumatic brain injury in TDP-43 transgenic mice: learning performance and some inflammation and stress parameters in the hippocampi}, keyword = {brain injuries, traumatic, hippocampus, mice, TDP-43 proteinopathies}, publisher = {EPHAR}, publisherplace = {Prag, \v{C}e\v{s}ka} }




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