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FTO gene polymorphisms rs9939609, rs1421085, and rs17817449 causeobesity through impact on serum lipids?

OBJECTIVE Fat mass and obesity- associated(FTO)gene has been linked to obesity and hypertensionin whole-genome- wide studies. The aim of the study was to determine the association of the FTO gene single nucleotide polymorphism (SNPs) rs9939609, rs1421085, and rs17817449 with changes in triglycerides(TG) and high- density lipoprotein (HDL) levels in obese women. METHODS 46 obese women volunteered to participate in the study (BMI ≥ 30 kg/m2). Genotyping of SNPs rs9939609, rs1421085, and rs17817449 in whole blood samples was performed by the real-time polymerase chain reaction (real-time PCR). Subject’s glucose and lipid values, blood pressure, and waist circumference were measured. To define dyslipidemia, a value ≥ 1.7mmol/L for triglycerides and ≤ 1.29 for HDL was taken as a cut-off. RESULTS All risk genotypes of the studied FTO gene polymorphisms (CC rs1421085, AA rs9939609 and GG rs17817449) were associated with higher BMI (P <0.05). All three examined SNPs had 39.13% homozygotes for the risk allele. There is no statistically significant association between FTO risk genotypes and dyslipidemia although subjects with dyslipidemia and rs17817449 (p=0, 37) and rs1421085 (p=0, 37) have more risk genotype than carriers of rs1787449 and rs1421085 without dyslipidemia (83, 33 % vs. 75 %). Subjects with dyslipidemia have less risk allele genotype of rs9939609 (p=0, 67) in compare to subjects without dyslipidemia for rs9939609 (73, 17 % vs 80 %). CONCLUSION These results indicate that FTO polymorphisms have no impact on lipid status in obese women. Association between higher triglycerides concertation and rs9939609 variant has previously been reported, while other studies reported no association between this polymorphism and lipids. FTO polymorphisms have an impact on assessing fullness, lower postprandial satiety. Many studies reported FTO rs9939609 is associated with higher fat intake while others observed increased protein intake. FTO gene impacts feeding behavior and energy homeostasis. Future studies should include a larger sample with included epigenetic factors such as lifestyle that could shed light on the influence of FTO expression.

FTO gene, dyslipidemia, single nucleotide polymorphism, obesity

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