The effects of chemically-functionalized single- walled carbon nanotubes on primary mouse astrocytes in an in vitro model of severe traumatic brain injury (CROSBI ID 727943)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Pilipović, Kristina ; Gržeta, Nika ; Harej Hrkać , Anja ; Parpura, Vladimir
engleski
The effects of chemically-functionalized single- walled carbon nanotubes on primary mouse astrocytes in an in vitro model of severe traumatic brain injury
Extensive research has proven that astrocytes, one of the key regulators of brain homeostasis, influence synaptic plasticity of the brain after traumatic brain injury (TBI). It has also been shown that dysregulation of the astrocyte function can lead to negative outcomes of brain trauma. Recently, a promising approach in TBI therapy is tissue engineering, which focuses on connecting the damaged parts of the brain and restoring its structure, and certain nanomaterials, such as the chemically- functionalized single-walled carbon nanotubes (SWCNTs), show potential for use in such cases. It was previously discovered that the application of SWCNTs decreases lesion volume and promotes neurite outgrowth in the rat model of spinal cord injury, and when applied to the culture medium, they modulate morpho- functional properties of astrocytes. However, it is still unknown how would the injured astrocytes react to SWCNTs exposure and if these effects would persist in pathological conditions. The purpose of the investigations of our research group is to determine whether the chemically-functionalized SWCNTs can affect the survival of the astrocytes and their proliferation, as well as influence their function in the in vitro model of TBI. In this presentation, the results of our research regarding the effects of SWCNTs on the astrocytes’ survival rate and oxidative stress following stretch injury will be shown. Also, we explored the changes in the secretory function of injured astrocytes and the influence of the application of the investigated nanomaterials. This research was fully supported by the Croatian Science Foundation grant UIP-2017-05-9517 to KP.
astrocytes ; mouse ; nanotubes, carbon ; brain injury, traumatic
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Podaci o prilogu
116-116.
2022.
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objavljeno
Podaci o matičnoj publikaciji
Mršić-Pelčić, Jasenka ; Vitezić, Dinko ; Janković, Tamara
Zagreb: Hrvatsko društv za kliničku farmakologiju i terapiju HLZ-a
0031-6857
Podaci o skupu
10. hrvatski kongres farmakologije ; 1. hrvatski kongres kliničke farmakologije s međunarodnim sudjelovanjem = 10th Croatian Congress of Pharmacology ; 1st Croatian Congress of Clinical Pharmacology and Therapeutics with International Participation
predavanje
22.09.2022-25.09.2022
Opatija, Hrvatska