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BIOLOGICAL ACTIVITY OF 3-AMINOQUINUCLIDINE QUARTERNARY SALT

Quaternary ammonium compounds (QACs) are amphiphilic compounds with exceptional properties and a wide range of applications. They display very good biological activities. Due to the development of bacterial resistance to QACs, the current aim is to synthesize new QACs which are biodegradable, but still efficient.1 Quaternization of heterocyclic quinuclidine and its derivatives has proven to be a good solution since its quaternary salts have great antibacterial and antifungal properties. For this research, the antibacterial activity of synthesized 3- aminoquinuclidine quaternary salt with an alkyl chain of 16 carbon atoms has been investigated by microdilution method on seven bacterial strains: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Salmonella enteritidis, Listeria monocytogenes and Bacillus cereus. The best MIC value obtained was 9 nM against two Gram- positive bacteria: L. monocytogenes ATCC 7644 and S. aureus ATCC 25923. The second-best MIC was against Gram-positive E. faecalis ATCC 29212 at 36 nM. Obtained values are considered the potential for future investigations of that quaternary ammonium salt.

Quaternary ammonium compounds, antibacterial properties, microdilution method

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