engleski

CONSTRUCTING THE HLA-DPB1 AND DPA1 POLYMORPHISM PICTURE IN EUROPEAN POPULATIONS – THE CROATIAN PIECE OF THE PUZZLE

Importance of HLA-DPB1 and DPA1 genes in solid organ and hematopoietic stem cell transplantation outcome has been increasingly studied in recent years and therefore the aim of this study was to analyze HLA-DBP1 and DPA1 allele and haplotype frequencies in the Croatian population (N=124). Eighteen different HLA-DPB1 alleles were observed among tested subjects, with HLA-DPB1*04:01 allele being the most frequent one (36.7%), followed by DPB1*04:02 and DPB1*02:01 alleles (16.1% and 15.7%, respectively). HLA-DPA1 locus showed limited diversity with only 6 different alleles, among which the most common was HLA-DPA1*01:03 allele (76.2%). Despite such small cohort and low HLA-DPA1 polymorphism one very rare allele was detected (DPA1*01:06:02). Percentage of heterozygotes was 79.8% for HLA-DPB1 and only 37.9% for HLA-DPA1 locus. Haplotype analysis revealed 24 different haplotypes, with HLA- DPB1*04:01~DPA1*01:03 and HLA- DPB1*04:02~DPA1*01:03 haplotypes being most commonly observed (36.3% and 16.1%, respectively). This study clearly demonstrates the necessity to further investigate HLA-DPB1 and DPA1 loci since a very limited number of studies focused on these genes and especially the perception of HLA-DPA1 as low polymorphism locus might change with more data available at higher resolution level.

HLA-DPA1 ; HLA-DPB1 ; polymorphism

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