engleski

Association of gene polymorphism MTHFR C677T and MTHFR A1298C with atrial fibrillation

While incidence of MTHFR C677T homozygous mutation TT was similar in our group of patients with AF as in general population in our geographic region, the incidence of MTHFR C677T heterozygous mutation (52.7%) was significantly higher than the incidence of general population ; approximately 20-40% of Caucasian.3 MTHFR A1298C homozygous mutation CC incidence in our group of patients with AF (14.5%) was higher than in European population (7-12%). Pathological MTHFR C677T and MTHFR A1298C polymorphisms distribution in our group of patients with AF, that includes high incidence of heterozygous mutation and higher incidence of homozygous mutation than in general population, could indicate association of pathological MTHFR polymorphisms with AF onset.

MTHFR C677T and MTHFR A1298C polymorphisms ; atrial fibrillation

nije evidentirano