engleski

A new solid-state promethazine hydrochloride-selective sensor based on functionalized MWCNT

Promethazine hydrochloride (PM) is a phenothiazine derivative widely used as antihistaminic, antiemetic, analgesic and anticholinergic drug. Also, it has anesthetic and sedative effect, and can be used as therapeutic agent for treating various mental disorders. Regardless of its benefits, it has adverse effects, such as endocrinal, cardiac and reproductive alterations. Considering that, its determination in pharmaceutical formulations and biological samples is important. Different analytical methods can be used for PM determination but they commonly have drawbacks such as expensive instrumentation, time consuming and complicated procedures, and use of toxic solvents. Due to their simplicity, ion-selective electrodes (ISEs) could be a good alternative. In order to develop ISEs with better properties, ISE membrane can be modified with multi-walled carbon nanotubes (MWCNT) considering their unique properties.4 The new solid-state PM-selective sensor, with liquid type of membrane, was developed using MWCNT functionalized with a sulfate group and PM ion as a sensor material. The new sensor was characterized using direct potentiometry. Response characteristics, dynamic response, influence of pH and selectivity were determined.

promethazine hydrochloride ; solid-state sensor ; direct potentiometry

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