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Pseudophakic Cystoid Macular Oedema (PCME) Prevention in Patients with Non-Proliferative Diabetic Retinopathy (NPDR)— Randomized Controlled Trial (CROSBI ID 316819)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Jukić, Anđela ; Kasalica Žužul, Rajka ; Pavan, Josip ; Lovrić, Mila ; Kozmar, Ana ; Plavec, Davor ; Kuzman, Tomislav ; Kalauz, Miro ; Jukić, Tomislav Pseudophakic Cystoid Macular Oedema (PCME) Prevention in Patients with Non-Proliferative Diabetic Retinopathy (NPDR)— Randomized Controlled Trial // Medicina, 58 (2022), 11; 1667, 13. doi: 10.3390/medicina58111667

Podaci o odgovornosti

Jukić, Anđela ; Kasalica Žužul, Rajka ; Pavan, Josip ; Lovrić, Mila ; Kozmar, Ana ; Plavec, Davor ; Kuzman, Tomislav ; Kalauz, Miro ; Jukić, Tomislav

engleski

Pseudophakic Cystoid Macular Oedema (PCME) Prevention in Patients with Non-Proliferative Diabetic Retinopathy (NPDR)— Randomized Controlled Trial

Background and Objectives: The purpose of this study was to compare the effect of topical bromfenac and dexamethasone on the intraocular concentration of interleukin 6 (IL-6) and incidence of pseudophakic cystoid macular oedema (PCME) after cataract surgery in patients with non-proliferative diabetic retinopathy (NPDR). Materials and Methods: Ninety eyes of patients with mild- to-moderate NPDR that underwent phacoemulsification cataract surgery were divided into three groups. A detailed description of the clinical study protocol is described later in paper. In short, Group 1 received topical bromfenac (0.9 mg/mL), Group 2 dexamethasone (1 mg/mL), and Group 3 placebo, both preoperatively and postoperatively. Additionally, all patients received combined topical steroid and antibiotic drops (dexamethasone, neomycin and polymyxin B) 3 weeks postoperatively. On the day of the surgery, aqueous humour samples (0.1–0.2 mL) were obtained and IL-6 concentrations were analysed. Central foveal subfield thickness (CFT) measured using spectral-domain optical coherence tomography (SD- OCT) was analysed preoperatively and postoperatively. Results: There was no significant difference in IL-6 concentrations between groups. Postoperative CFT was significantly lower in the dexamethasone group compared to the placebo group. In addition, the correlation between IL-6 and CFT was statistically significant in the dexamethasone group. No patient developed PCME in any of the three groups. No adverse events were reported during the study. Conclusion: Topical bromfenac and dexamethasone have no significant effect on intraocular IL-6 concentration in patients with NPDR. Topical bromfenac is not more effective than topical dexamethasone in reducing postoperative CFT in patients with NPDR.

pseudophakic cystoid macular oedema (PCME) ; central foveal subfield thickness (CFT) ; interleukin 6 (IL-6) ; non-proliferative diabetic retinopathy (NPDR)

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Podaci o izdanju

58 (11)

2022.

1667

13

objavljeno

1010-660X

1648-9144

10.3390/medicina58111667

Trošak objave rada u otvorenom pristupu

Povezanost rada

Kliničke medicinske znanosti

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