engleski

SCORE risk in metabolically healthy obese patients

Introduction: Although all obese patients according to the WHO classification have a high risk for health, the latest research shows that this is not always the case. Objective: The aim of this study is to show whether metabolically healthy obese (MHO) people have a lower risk for cardiovascular risk events (by SCORE2 risk) compared to metabolically unhealthy obese people (MUO) according to several different criteria. Methods: This cross-sectional study included 169 obese patients (average age 44 years) treated at the Clinic for Endocrinology of University Hospital Center Zagreb. MHO is defined using four separate criteria (general, Meigs, Karelis, Angulinar-Salin) which, depending on the criteria, include laboratory values of fasting glucose, triglycerides, cholesterol, waist circumference, blood pressure, and HOMA index. Risk for cardiovascular events is calculated by SCORE2 and ASCVD risk. Mann-Whitney U test and ordinary descriptive statistics were used in Statistica v.12. Results: A significantly lower SCORE2 risk was found in MHO individuals depending on a criterion: 1)Meigs criterion: 57 patients had MHO with SCORE2 risk median 3.0 [1.0-7.0] vs. 5.0 [3.0-8.0] in MUO (p=0.044). 2) Angulinar-Salin criterion: 76 patients had MHO with SCORE2 risk median 3.0 [1.0- 5.5] vs.5.0 [3.0-8.0] (p0.001). In other two groups of patients SCORE2 risk was not lower in MHO than in MUO individuals: 1) General criterion: 46 patients had MHO with SCORE2 risk median 3.0 [1.5-5.5] vs. 4.5 [2.0-8.0] in MUO (p=0.088). 2) Karelis criterion: 24 patients had MHO with SCORE2 risk median 4.0 [1.0-6.0] vs. 4.0 [2.0-8.0] in MUO (p=0.434). Spearman correlation between SCORE2 and ASCVD risks was 0.817 (p0.001). Conclusion: The total risk in MHO individuals according to two of four evaluated criteria (Meigs and Angulinar-Salin criterion) was significantly lower than in MUO individuals. Studies on a larger number of subjects are needed to confirm the stated claims.

Cardiovascular risk ; Metabolically healthy obese ; Obesity

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