Chromosomal abnormalities in childhood lymphomas (CROSBI ID 466161)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Petković, Iskra ; Ćepulić, Mladen ; Konja, Josip ; Vrdoljak, Javor.
engleski
Chromosomal abnormalities in childhood lymphomas
This study presents the results of cytogenetic analysis in children with malignant lymphoma. The aim of this investigation was to define the frequency abd types of clonal chromosomal abnormalities in malignant cells in our group of childhood non-Hodgkin's lymphoma.Our investigation included 16 children, 4 girls and 12 boys aged from 9 nmonths to 15 years.Cytogenetic analysis of malignant cells was carried out at diagnosis and before initiating therapy. Slides were obtained from direct or short-term culture of lymphonode, and / or bone marrow cells. Chromosome identification was carried out using the G-banding method. Chromosomal abnormalities were described according to the International System for Human Cytogenetic Nomenclature (1991). Cytogenetic analysis revealed clonal chromosomal abnormalities in 11 (68.7%) out of 16 children.Chromosomal instability and evidence of clonal evolution were observed in 3 patients. Pseudodiploid clone was observed in 4, hyperdiploid in 5 and hypotriploid in 2 out of 11 children with clonal chromosomal aberrations. This investigation revealed complex numerical and structural aberrations. the gain of some chromosometypes were nonrandom and frequently affected chromosomes were 11, 14, 21, and X. involvement of particular chromosome tapes in structural abnormalities was nonrandom too. Chromosome No.1 and No.14 were abnormal in 5 and 4 cases respectively. This investigation confirms variability of clonal chromosomal aberrations and cytogenetic heterogeneity of childhood non-Hodgkin lymphomas. Additional investigations are, however , necessary to define more presisely the frequency and types of aberrations, and biological role of chromosomal regions in the development of NHL.
Cytogenetics; lymphoma; children
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Podaci o prilogu
458-458-x.
1997.
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objavljeno
Podaci o matičnoj publikaciji
Medical and Pediatric Oncology
International Society of Pediatric Oncology
Istanbul: Wiley-Liss
Podaci o skupu
SIOP XXIX. Meeting
poster
23.09.1997-27.09.1997
Istanbul, Turska