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Pregled bibliografske jedinice broj: 123238

Changes in plasma lipids after a non-lethal dose of cycloheximide in rats


Lucić, Ana; Bradamante, Vlasta; Peraica, Maja; Radić, Božica; Domijan, Ana-Marija; Fuchs, Radovan
Changes in plasma lipids after a non-lethal dose of cycloheximide in rats // Human and Experimental Toxicology, 22 (2003), 245-248 (međunarodna recenzija, članak, znanstveni)


Naslov
Changes in plasma lipids after a non-lethal dose of cycloheximide in rats

Autori
Lucić, Ana ; Bradamante, Vlasta ; Peraica, Maja ; Radić, Božica ; Domijan, Ana-Marija ; Fuchs, Radovan

Izvornik
Human and Experimental Toxicology (0960-3271) 22 (2003); 245-248

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cikloheksimid; HDL; Kolesterol; sinteza proteina; ukupni kolesterol; trigliceridi
(Cycloheximide; protein synthesis; triglycerides; total cholesterol; HDL-cholesterol)

Sažetak
This paper describes a study of the effect of a single intraperitoneal non-lethal dose of cycloheximide (CHM ; 2.0 mg/kg body weight) on the concentration of plasma lipids and lipoproteins in male rats killed 1, 2, 3, 4 and 9 days after receiving the dose. The concentration of triglycerides, total cholesterol, high-density lipoproteins (HDL)-cholesterol and low-density lipoproteins (LDL)-cholesterol was measured in treated and control animals. The effect of CHM on the concentration of triglycerides, total cholesterol, HDL-cholesterol, and LDL-cholesterol was visible in rat plasma throughout the study. Total cholesterol and HDL-cholesterol concentrations showed the same pattern of changes, probably due to the reversible inhibition of apolipoprotein apo A-I synthesis by CHM. The concentration of triglycerides decreased after a lag period of 3 days when the reserves of apolipoprotein apo B, the main apolipoprotein of very low-density lipoproteins (VLDL)-cholesterols produced in liver, were consumed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0022015
0022018
0108039

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts