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izvor podataka: crosbi

Relevance of CYP2D6 Gene Variants in Population Genetic Differentiation (CROSBI ID 316574)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Stojanović Marković, Anita ; Zajc Petranović, Matea ; Škarić-Jurić, Tatjana ; Celinšćak, Željka ; Šetinc, Maja ; Tomas, Željka ; Peričić Salihović, Marijana Relevance of CYP2D6 Gene Variants in Population Genetic Differentiation // Pharmaceutics, 14 (2022), 11; 2481, 14. doi: 10.3390/pharmaceutics14112481

Podaci o odgovornosti

Stojanović Marković, Anita ; Zajc Petranović, Matea ; Škarić-Jurić, Tatjana ; Celinšćak, Željka ; Šetinc, Maja ; Tomas, Željka ; Peričić Salihović, Marijana

engleski

Relevance of CYP2D6 Gene Variants in Population Genetic Differentiation

A significant portion of the variability in complex features, such as drug response, is likely caused by human genetic diversity. One of the highly polymorphic pharmacogenes is CYP2D6, encoding an enzyme involved in the metabolism of about 25% of commonly prescribed drugs. In a directed search of the 1000 Genomes Phase III variation data, 86 single nucleotide polymorphisms (SNPs) in the CYP2D6 gene were extracted from the genotypes of 2504 individuals from 26 populations, and then used to reconstruct haplotypes. Analyses were performed using Haploview, Phase, and Arlequin softwares. Haplotype and nucleotide diversity were high in all populations, but highest in populations of African ancestry. Pairwise FST showed significant results for eleven SNPs, six of which were characteristic of African populations, while four SNPs were most common in East Asian populations. A principal component analysis of CYP2D6 haplotypes showed that African populations form one cluster, Asian populations form another cluster with East and South Asian populations separated, while European populations form the third cluster. Linkage disequilibrium showed that all African populations have three or more haplotype blocks within the CYP2D6 gene, while other world populations have one, except for Chinese Dai and Punjabi in Pakistan populations, which have two.

CYP2D6 gene ; polymorphism ; haplotype ; star allele ; pharmacogenetics ; 1000 Genomes populations

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

14 (11)

2022.

2481

14

objavljeno

1999-4923

10.3390/pharmaceutics14112481

Povezanost rada

Biologija, Etnologija i antropologija, Javno zdravstvo i zdravstvena zaštita

Poveznice