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The effects of moderate red wine consumption on arterial stiffness and hemodynamic parameters in type 2 diabetes mellitus

Introduction Assessment of carotid-femoral pulse wave velocity (PWV), a direct measure of arterial stiffness, could serve as useful tool in the early detection of type 2 diabetes mellitus (T2DM) patients at high risk of cardiovascular events. Moderate red wine consumption has been linked to cardiovascular benefits among both healthy persons and diabetic patients. We aimed to determine whether the daily intake of a 300 ml of red wine for 3 weeks affect PWV and hemodynamic parameters in T2DM patients. Subjects and Methods In the 5- weeks cross-over interventional trial of 18 T2DM participants we assessed changes in PWV and hemodynamic parameters (heart rate, peripheral and central systolic, diastolic and pulse pressures). All participants underwent an initial 2 weeks- drive in period with no alcohol consumption (baseline) followed by 3-weeks of wine consumption period. The measurements were performed at the end of each period by applanation tonometry using the SphygmoCor® device. Results Moderate RW consumption was associated with significant decrease in PWV from 7.42±1.44 m/s at baseline to 6.98±1.44 m/s at the end of wine consumption period. Peripheral arterial diastolic pressure also decreased from baseline 79.72±11.47 mmHg to 76.39±11.15 mmHg at the end of wine consumption period. Conclusion In a cohort of diabetic patients without clinical symptoms of cardiovascular disease, relatively short period of moderate red wine consumption resulted in improvement of cardiovascular hemodynamics.

red wine ; arterial stiffness ; hemodynamic parameters ; type 2 diabetes mellitus

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